A new pill that repeats exercises and strengthens muscles

Men's upper body fitness strength energy

Researchers have discovered that the drug has similar effects to exercise.

Researchers at Tokyo Medical and Dental University have discovered a drug that replicates the benefits of exercise on the bones and muscles of mice.

You can look and feel better by sticking to a regular exercise schedule, but did you know that exercise also supports bone and muscle health? Osteoporosis, which affects people who are unable to exercise, causes muscle and bone deterioration. Japanese researchers recently discovered a new drug that may help treat motor impairment by producing effects similar to those of exercise.

Physical inactivity can lead to weakness of muscles (known as sarcopenia) and weakness of bones (known as osteoporosis). Exercise dispels this weakness by enhancing muscular strength and suppressing bone resorption while simultaneously promoting bone formation. However, exercise therapy cannot be used in every clinical case. When patients have dementia, cerebrovascular disease, or are already bedridden, drug therapy may be very helpful in treating sarcopenia and osteoporosis. However, there is no single drug that targets both tissues at the same time.

Lams antibacterial drug

Exercise stimulates calcium signals in the muscles and bones. Under this signal, PGC-1α is activated, leading to hypertrophy of these tissues. LAMZ, a newly identified tractor-mimicking drug, has been found to facilitate the calcium signaling pathway and restore locomotor fitness. Credit: Cell Signaling Division, TMDU

researchers from Tokyo Medical and Dental University (TMDU) A new drug screening system was used in a recent study published in the journal orthopedic research To identify a compound that replicates changes in the muscles and bones that arise from exercise. Using the screening system, the researchers discovered the aminoindazole derivative locamidazole (LAMZ). LAMZ has the ability to stimulate the growth of bone-forming osteoblasts and muscle cells while inhibiting the formation of osteoclasts, which break down bone.

LAMZ was successfully transferred into the bloodstream of rats when administered orally, without any apparent side effects. Takehito Ono, the study’s lead author, stated, “We were pleased to find that the Plums-treated mice showed greater muscle fiber width, greater maximal muscle strength, a higher rate of bone formation, and lower bone uptake activity.”

The research team also examined the way the LAMZ function and found that LAMZ mimics the calcium and PGC-1α signaling pathways. These pathways are activated during exercise and stimulate the expression of downstream molecules that are involved in maintaining muscle and bone.

To check if LAMZ can treat motor impairment, LAMZ was administered to an animal model of sarcopenia and osteoporosis. “Oral and subcutaneous administration of the drug improved the muscles and bones of rats with motor impairment,” says senior author Tomoki Nakashima.

Taken together, the research team’s findings show that LAMZ represents a potential therapeutic method for treating motor impairment by simulating exercise.

Reference: “Simultaneous augmentation of muscle and bone by kinetic mimicry through calcium-PGC-1α signaling” By Takehito Ono, Ryosuke Denda, Yuta Tsukahara, Takashi Nakamura, Kazuo Okamoto, Hiroshi Takayanagi, and Tomoki Nakashima, August 3, 2022, orthopedic research.
DOI: 10.1038 / s41413-022-00225-w

The study was funded by the Japan Science and Technology Agency, Japan Medical Research and Development Agency, Japan’s Ministry of Education, Culture, Sports, Science and Technology, Daiichi Sankyo Life Science Foundation, Takeda Science Foundation, and Secom Science and Technology Foundation.

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